Coronary disease & ACSCohort study
Prognostic Value of Poststenting Fractional Flow Reserve After Imaging-Guided Optimal Stenting
- Registry-based cohort study
Authors' conclusion
Poststenting FFR showed a significant association with cardiac events. However, its prognostic value appeared to be limited after the application of an imaging-guided optimal stenting strategy.
Study context
- Population
- Patients with poststenting fractional flow reserve (FFR) assessment, IRIS-FFR registry
- Participants
- 1,005 patients · 1,108 lesions
- Exposure
- Poststenting FFR by iPSP strategy
- Outcome
- TVF (cardiac death, target vessel MI or target vessel revascularization)
- Follow-up
- 5 years
Main finding
TVF per 0.01 increase of poststenting FFR
Adjusted hazard ratio
0.94
95% CI 0.90–0.98
P = 0.004
Overall population
aHR 0.94 (95% CI 0.90–0.98); P = 0.004
Per 0.01 increase of FFR, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| TVF per 0.01 increase of poststenting FFR, by iPSP strategy (subgroup) · 5 years — iPSP · per 0.01 increase of FFR | 1.00 (0.96–1.05) | P = 0.95 | |
| TVF per 0.01 increase of poststenting FFR, by iPSP strategy (subgroup) · 5 years — No iPSP · per 0.01 increase of FFR | 0.94 (0.90–0.99) | P = 0.009 | |
| 0.512Adjusted hazard ratio (log scale) |
- Lesions treated with all 3 parts of iPSP · index procedure
- 29.4% · 326 events
- Target vessel failure (TVF) per 0.01 increase of poststenting FFR, by iPSP strategy (subgroup): interaction P = 0.045
Original publication
Prognostic Value of Poststenting Fractional Flow Reserve After Imaging-Guided Optimal Stenting. JACC Cardiovasc Interv. Published 8 April 2024. doi:10.1016/j.jcin.2024.01.313
Summarised from the published abstract; every number is checked against it