Heart failure & cardiomyopathiesCohort study
Prognostic value of pulmonary transit time by cardiovascular MRI in heart failure with preserved ejection fraction
- prospective cohort
- multiparametric cardiovascular magnetic resonance (CMR)
- Multivariable Cox proportional hazard regression
Authors' conclusion
Prolonged PTT is an independent predictor of death or heart failure hospitalisation in HFpEF. As an easily obtainable and integrative CMR biomarker of cardiopulmonary haemodynamics, PTT may improve risk stratification in HFpEF, although its clinical application requires further investigation.
Study context
- Population
- Adult patients with heart failure with preserved ejection fraction (HFpEF)HFpEF patients studied, median follow-up 7.7 years
- Participants
- One-hundred and eighteen patients
- Exposure
- Prolonged pulmonary transit time (PTT) and the composite outcome
- Outcome
- Composite of:
- Heart failure hospitalisation
- All-cause mortality
- Follow-up
- Median 7.7 years
Main finding
As reported in the abstract
Prolonged PTTHazard ratio (CI)P value
clinical model
2.222(1.222–4.041)
P = 0.009blood biomarker model
1.776(1.022–3.087)
P = 0.042imaging model
2.108(1.115–3.983)
P = 0.020combined model incorporating the strongest markers
2.989(1.612–5.543)
P < 0.001- Composite events
- Eighty-one
- Heart failure hospitalisations
- 50
- Deaths
- 31
Observational data: associations, not effects.
Original publication
Prognostic value of pulmonary transit time by cardiovascular MRI in heart failure with preserved ejection fraction. Heart. Published 28 May 2026. doi:10.1136/heartjnl-2026-328139
Summarised from the published abstract; every number is checked against it