Valvular & structural heart diseaseCohort study
Prognostic value of transaortic flow rate compared with ejection fraction and stroke volume index in low-gradient severe aortic stenosis
- retrospective
- Mayo Clinic sites (2017-2023)
Authors' conclusion
In patients with symptomatic low-gradient severe AS, low TAFR, not SVI or LVEF, is independently associated with mortality and may offer more accurate measure of flow state for clinical staging.
Study context
- Population
- Patients with symptomatic low-gradient severe aortic stenosis (AS) (AVA ≤1 cm 2 and Vmax <4 m/s or MG <40 mm Hg) who underwent transcatheter aortic valve replacementpatients included (mean age 85±8 years, 49% women)
- Participants
- 475 patients
- Exposure
- Prognostic value of transaortic flow rate (TAFR) compared with LVEF and stroke volume index (SVI)
- TAFR <220 mL/sn = 242
- EF <50%n = 165
- SVI <35 mL/m 2n = 221
- Outcome
- 1-year all-cause mortality
- Follow-up
- 1-year
Main finding
As reported in the abstract
Hazard ratio
2.38
95% CI 1.19–4.76
P = 0.014
TAFR
HR 2.38 (95% CI 1.19–4.76); P = 0.014
Observational data: associations, not effects.
Original publication
Prognostic value of transaortic flow rate compared with ejection fraction and stroke volume index in low-gradient severe aortic stenosis. Heart. Published 14 April 2026. doi:10.1136/heartjnl-2025-327594
Summarised from the published abstract; every number is checked against it