Arrhythmias & electrophysiologyCohort study
Prognostic value of ventricular arrhythmia in early post-infarction left ventricular dysfunction: the French nationwide WICD-MI study
- Retrospective cohort study
- nationwide registry
- consecutive patients
Authors' conclusion
In patients with LVEF ≤ 35%, sustained VA during the early post-infarction phase is predictive of recurrent sustained VAs and 1-year mortality.
Study context
- Population
- Patients with left ventricular ejection fraction (LVEF) ≤ 35% after acute MI, prescribed a wearable cardioverter-defibrillator (WCD) for 3 months after discharge and then implanted with an ICDmedian follow-up 30.9 months
- Participants
- 1,032 patients
- Exposure
- Sustained VA while on WCD vs no sustained VA while on WCD
- VA+/WCDn = 72
- VA-/WCDn = 960reference
- Outcome
- Recurrence of sustained ventricular arrhythmias (VAs)
- Follow-up
- 1 year after ICD implantation
Main finding
As reported in the abstract
Sustained VAs within 1 year after ICD implantation · 1 year
Adjusted hazard ratio
6.91
95% CI 3.73–12.81
P < 0.0001
By group
VA+/WCD vs VA-/WCD
adjusted HR 6.91 (95% CI 3.73–12.81); P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Recurrence of sustained VAs at end of follow-up | 3.86 (2.37–6.30) | P < 0.0001 | |
| 1-year mortality | 2.86 (1.28–6.39) | P = 0.012 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Original publication
Prognostic value of ventricular arrhythmia in early post-infarction left ventricular dysfunction: the French nationwide WICD-MI study. Eur Heart J. Published 20 September 2024. doi:10.1093/eurheartj/ehae575
Summarised from the published abstract; every number is checked against it