Valvular & structural heart disease
Prospective validation of a prespecified algorithm for the management of conduction disturbances after transcatheter aortic valve replacement: The PROMOTE study
Authors' conclusion
A prespecified strategy for the management of CDs in contemporary TAVR recipients was feasible and safe, with no increased mortality and an extremely low rate of sudden cardiac death in patients with CDs. However, PPM rates remained high
Study context
- Population
- Consecutive patients without prior pacemaker undergoing transcatheter aortic valve replacement (TAVR)
- Participants
- 2,110 patients
- Exposure
- Prespecified CD management algorithm by group
- Outcome
- Permanent pacemaker (PPM) and mortality (overall, sudden cardiac death)
- Follow-up
- 30 days
Methodological detailsmulticentre, consecutive patients, prespecified management algorithm
- Multicentre
- Consecutive patients
- Prespecified management algorithm
Main finding
As reported in the abstract
PPM, all-cause mortality and SCD at 30 days
PPM
P < 0.001
All-cause mortality
P = 0.45
SCD
P = 0.99
- Permanent pacemaker (PPM) overall at 30 days
- 329 (15.6%)
Observational data: associations, not effects.
Further findings
PPM by procedural CD type · 30 days
- New-onset LBBB
- 17.4%
- High-degree AV block/complete heart block
- 57.2%
Original publication
Prospective validation of a prespecified algorithm for the management of conduction disturbances after transcatheter aortic valve replacement: The PROMOTE study. Heart Rhythm. Published 16 December 2024. doi:10.
Summarised from the published abstract; every number is checked against it