Propensity Score Analysis of Possible Medication Effects on Outcomes in Patients With Systemic Right Ventricles
Authors' conclusion
In this large multicenter propensity-matched observational study, patients with SRV taking beta-blockers or ACEI/ARB did not have a benefit in survival or reduced hospitalization.
Study context
- Population
- Patients with systemic RV (d-transposition after atrial switch or congenitally corrected transposition of the great arteries)median follow-up ∼8 years
- Participants
- 393 vs 484
- Exposure
- ACEi/ARB and/or beta-blocker vs neither
- Angiotensin-converting enzyme inhibitors (ACEI)/ARB or beta-blockern = 393
- Neithern = 484reference
- Outcome
- Death, transplant, or mechanical circulatory support
Methodological detailsmulticentre, propensity-score matched
- Multicentre
- Propensity-score matched
Main finding
As reported in the abstract
- After propensity matching, medication use not associated with decreased mortality
- Propensity-matched
Observational data: associations, not effects.
Secondary outcomes
- Medication use not associated with decreased HF hospitalizations or arrhythmias
- HRs remained positive for beta-blockers, implying potential harm rather than benefit
Original publication
Propensity Score Analysis of Possible Medication Effects on Outcomes in Patients With Systemic Right Ventricles. JACC Adv. Published 13 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →