Prevention & lipidsCohort study
Prospective evaluation of a self-report-guided strategy for targeted coronary artery calcium imaging
- prospective, two-step, population-based screening approach
Authors' conclusion
A self-report-guided strategy enabled targeted CAC imaging in a model-selected cohort. Among participants completing CT imaging, the observed prevalence of CAC ≥100 was comparable with the mean model-predicted probability. These findings suggest that self-report data may support preselection for CAC imaging and help identify opportunities for preventive treatment among individuals with elevated CAC.
Study context
- Population
- Individuals aged 59–60 years without previous ischaemic heart disease, selected by a self-report-based model of the probability of coronary artery calcium (CAC) ≥100invited individuals, 2588 (32%) completed the questionnaire, 2375 eligible respondents, 814 classified as high risk, 563 underwent CT imaging
- Participants
- 8,000 individuals
- Exposure
- Model-predicted probabilities vs the observed prevalence of CAC ≥100 among CT completers
- Outcome
- Agreement between model-predicted probabilities and the observed prevalence of CAC ≥100 among CT completers
Main finding
As reported in the abstract
Mean predicted probability of CAC ≥100
28.3% (95% CI 27.2 to 29.3)
Observed prevalence of CAC ≥100
28.4% (95% CI 24.8 to 32.4)
Expected/observed ratio
0.99
Brier score
0.19
Observational data: associations, not effects.
Further findings
Preventive lipid-lowering therapy among participants with CAC ≥100
- Of those with CAC ≥100, not receiving lipid-lowering therapy
- 64%
- Of those with CAC ≥100, low-density lipoprotein cholesterol ≤1.8 mmol/L
- 11%
Original publication
Summarised from the published abstract; every number is checked against it