Heart failure & cardiomyopathiesCohort study
Prospective systematic screening for transthyretin amyloid cardiomyopathy in cardiology inpatients with left ventricular hypertrophy: the IMPACT study
- prospective single-centre study
- consecutive patients
- systematic screening
Authors' conclusion
In a minimally selected cardiology population with LVH, systematic screening identified a substantial prevalence of ATTR-CM. BLS may help prioritize diagnostic testing in routine practice and facilitate earlier identification and management of ATTR-CM.
Study context
- Population
- Consecutive patients aged ≥60 years hospitalized in cardiology with echocardiographic left ventricular hypertrophy (LVH) (wall thickness ≥12 mm), irrespective of aetiology; excluding known amyloidosis, prior heart transplantation, or contraindication to scintigraphypatients screened between October 2021 and June 2023
- Participants
- 400 patients
- Exposure
- ATTR-CM vs non-ATTR-CM patients
- ATTR-CMn = 29
Main finding
As reported in the abstract
Prevalence of ATTR-CM
ATTR-CM diagnosed
29 of 400 patients (7.3%)
Observational data: associations, not effects.
Further findings
Variables independently associated with ATTR-CM (multivariable logistic regression)
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| basal longitudinal strain (BLS) | 0.84 (0.74–0.95) | ||
| non-sinus rhythm | 3.85 (1.30–11.11) | ||
| bilateral carpal tunnel syndrome | 3.48 (1.09–11.14) | ||
| history of stroke | 8.67 (2.65–28.34) | ||
| 0.050.21520Odds ratio (log scale) |
| Outcome | Estimate | P value |
|---|---|---|
| All-cause mortality · median follow-up of 3.31 years · did not significantly differ | P = 0.137 |
Discrimination for ATTR-CM
- Basal longitudinal strain (BLS) showed the highest discrimination for ATTR-CM (AUC)
- 0.81
Original publication
Prospective systematic screening for transthyretin amyloid cardiomyopathy in cardiology inpatients with left ventricular hypertrophy: the IMPACT study. Eur Heart J Cardiovasc Imaging. Published 15 September 2026. doi:10.1093/ehjci/jeag254
Summarised from the published abstract; every number is checked against it