Heart failure & cardiomyopathies
Protein Biomarkers of Adverse Clinical Features and Events in Sarcomeric Hypertrophic Cardiomyopathy
Authors' conclusion
Proteomic profiling of sarcomeric HCM identified biomarkers associated with adverse imaging and clinical phenotypes.
Study context
- Population
- Patients with genotype-positive (sarcomeric) hypertrophic cardiomyopathy in the hypertrophic cardiomyopathy (HCM) Registry275 proteins measured
- Participants
- 701 patients
- Outcome
- Associations of plasma protein levels with clinical features, CMR metrics and incident AF
Methodological detailsplasma proteomic profiling, HCM Registry
- Plasma proteomic profiling
- HCM Registry
Main finding
As reported in the abstract
- Late gadolinium enhancement associated with neurohormonal activation proteins (NT-proBNP, ACE2)
- LV remodeling metrics associated with vascular development/homeostasis proteins (VEGF-D, thrombomodulin)
- ESC SCD risk score inversely associated with stem cell factor
- Incident AF associated with inflammation and fibrosis mediators (MMP2, SPON1)
Observational data: associations, not effects.
Original publication
Protein Biomarkers of Adverse Clinical Features and Events in Sarcomeric Hypertrophic Cardiomyopathy. Circ Heart Fail. Published 5 November 2024. doi:10.
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