Heart failure & cardiomyopathies
Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study
Authors' conclusion
A multiprotein biomarker approach improves prediction of incident HF when added to natriuretic peptides and clinical risk factors.
Study context
- Population
- Participants of the HOMAGE cohort, ARIC study and FHSARIC 250/250, FHS 191/191, HOMAGE 562/871
- Comparison
- Clinical risk factors plus NT-proBNP plus multiprotein biomarkers vs clinical risk factors plus NT-proBNP
- Outcome
- Increment in C-index for incident HF with a multiprotein biomarker approach added to clinical risk factors and NT-proBNP
Methodological details3 independent cohorts, matched on age and sex, Plasma concentrations of 276 proteins measured at baseline
- 3 independent cohorts
- Matched on age and sex
- Plasma concentrations of 276 proteins measured at baseline
Main finding
As reported in the abstract
Increment in C-index for incident HF (multiprotein added to clinical risk factors and NT-proBNP)
- ARIC
- 11.1% (7.5%-14.7%)
- FHS
- 5.9% (2.6%-9.2%)
- HOMAGE
- 7.5% (5.4%-9.5%)
- All cohorts
- P<0.001
Observational data: associations, not effects.
Further findings
Proteins associated with incident heart failure (HF) (single protein analysis, adjusted, corrected for multiple testing)
- ARIC
- 62
- FHS
- 16
- HOMAGE
- 116
- Associated in all cohorts: BNP, NT-proBNP, 4E-BP1, hepatocyte growth factor (HGF), Gal-9, TGF-alpha, THBS2, U-PAR
Network analysis
- Overrepresented pathways related to inflammation (eg, tumor necrosis factor, interleukin) and remodeling (eg, extracellular matrix, apoptosis)
Original publication
Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circ Heart Fail. Published 16 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →