Heart failure & cardiomyopathiesCase-control study
Proteomic Profiling in Patients With Peripartum Cardiomyopathy
- Case-control proteomic study
- untargeted serum proteome profiling
- matched healthy controls
- 10-fold cross-validation
Authors' conclusion
Salient biologic themes related to immune response proteins, inflammation, fibrosis, angiogenesis, apoptosis, and coagulation were predominant in patients with PPCM compared with HCs.
Study context
- Population
- Patients with newly diagnosed peripartum cardiomyopathy and matched healthy postpartum mothers
- Participants
- 84 vs 29
- Comparison
- PPCM vs postpartum healthy controls
- PPCMn = 84
- Healthy controls (HCs)n = 29reference
- Outcome
- Serum proteome profile and diagnostic performance (AUC) of protein biomarkers to distinguish PPCM from HCs
Main finding
As reported in the abstract
Differentially expressed proteins and diagnostic performance
Differentially up-regulated proteins in PPCM vs HCs
15
Differentially down-regulated proteins in PPCM vs HCs
14
Proteins significant by Boruta algorithm
7
AUC of adiponectin + quiescin sulfhydryl oxidase 1 + inter-α-trypsin inhibitor heavy chain + NT-proBNP (best diagnostic precision), 95% CI 0.84-0.96
0.90
Observational data: associations, not effects.
Further findings
Mean
| Outcome | PPCM | HCs | P value |
|---|---|---|---|
| LVEF | 33.5% (SD 9.3%) | 57.0% (SD 8.8%) | P < 0.001 |
Original publication
Proteomic Profiling in Patients With Peripartum Cardiomyopathy. JACC Heart Fail. Published 4 October 2023. doi:10.1016/j.jchf.2023.07.028
Summarised from the published abstract; every number is checked against it