Arrhythmias & electrophysiologyDiagnostic or prognostic study
Proteomic signatures for sudden cardiac death and related intermediate phenotypes
- Protein risk score developed using lasso-penalized Cox regression and validated
- UK Biobank Pharma Proteomics Project
- derivation at English centers, validation at remaining centers
Authors' conclusion
A protein risk score derived from a single plasma sample significantly improved risk prediction of SCD and related intermediate phenotypes.
Study context
- Population
- General population individuals with plasma protein measurements from the UK Biobank Pharma Proteomics Projectindividuals with 1459 unique plasma protein measurements · Derivation (English centers) 40,722 · Validation (remaining centers) 11,983
- Participants
- 52,705 individuals
- Comparison
- Protein risk score added to sudden cardiac death (SCD) clinical risk factors vs SCD clinical risk factors alone
Performance
As reported in the abstract
SCD per standard deviation increase in protein risk score (test set)
Hazard ratio
2.60
95% CI 2.12–3.18
per standard deviation increase in protein risk score
hazard ratio 2.60 (95% CI 2.12–3.18)
Per standard deviation increase in protein risk, as printed
Further findings
Concordance index for SCD, protein risk score added to clinical risk factors
- concordance index increase
- 0.063 (95% CI 0.037-0.105)
Concordance index for ventricular arrhythmia-mediated SCDs
- increase in concordance index
- 0.070 (95% CI 0.010-0.188)
Risk reclassification · 10-year risk threshold of 5%
- risk reclassification
- 16.9% (95% CI 9.0-24.7)
Intermediate phenotypes of SCD
- Significantly associated with corrected QT prolongation, an increase in left ventricular mean myocardial thickness, and a decrease in left ventricular global longitudinal strain
Protein risk score composition
- unique plasma proteins in score
- 64
Original publication
Proteomic signatures for sudden cardiac death and related intermediate phenotypes. Heart Rhythm. Published 2 March 2026. doi:10.1016/j.hrthm.2026.02.039
Summarised from the published abstract; every number is checked against it