Heart failure & cardiomyopathiesDiagnostic or prognostic study
Proteomic Signatures of Cardiac Dysfunction Among People With Diabetes: The Atherosclerosis Risk in Communities Study
- discovery and internal validation
- external validation in the MESA study
- pathway analyses
Authors' conclusion
We identified 5 proteomic markers (4 novel) uniquely related to HF risk among individuals with diabetes and not among those without diabetes.
Study context
- Population
- ARIC study participants free of heart failure (HF), by diabetes statusARIC participants free of HF, external validation in MESA n=5233, 633 with diabetes · MESA 5,233 · individuals with diabetes in the discovery sample 993
- Participants
- 10,189 participants
- Comparison
- associations of 4955 plasma proteins with HF by diabetes status
Performance
As reported in the abstract
HF events · Over 24 years in ARIC
diabetes
605
events
- HF events, all participants
- 2417
Further findings
Proteins associated with HF in individuals with diabetes
- proteins associated with HF in discovery sample (P <10 −5 )
- 19
- proteins replicated in internal validation sample (P <0.05/19)
- 12
- internally validated proteins replicated in MESA (false discovery rate, q<0.05)
- Six
- proteins specifically associated with HF in those with diabetes (4 novel, 1 previously known: cartilage intermediate layer protein 2)
- Five
- NPPB (N-terminal pro-BNP) associated with HF in those with and without diabetes
Pathway analyses
- Pathways over-represented: lipid metabolism, inflammation, and brown adipose tissue
- q<0.05
Original publication
Proteomic Signatures of Cardiac Dysfunction Among People With Diabetes: The Atherosclerosis Risk in Communities Study. Circ Heart Fail. Published 22 January 2026. doi:10.1161/circheartfailure.125.013171
Summarised from the published abstract; every number is checked against it