Coronary disease & ACSRandomised controlled trial
Protocol-Based Implementation of Early Intensive Lipid Management After Acute Coronary Syndrome
- Cluster-randomised controlled trial
- 10 centres
- 1:1
Authors' conclusion
A protocol-based implementation strategy for early intensive LLT significantly improved achievement of the guideline-recommended LDL-C target after ACS.
Study context
- Population
- Patients with acute coronary syndrome (ACS)315 in primary analysis
- Participants
- 329 patients
- Comparison
- Protocol-based vs standard lipid management after ACS
Primary result
As reported in the abstract
Low-density lipoprotein cholesterol (LDL-C) <70 mg/dL achieved, protocol-based vs standard
86.4% vs 73.7%
Between-group difference
12.6 percentage points (95% CI: 3.8-21.5); P = 0.005
Hospital-level sensitivity analysis: difference
12.8 percentage points (95% CI: −2.0 to 27.6); P = 0.08
Secondary outcomes
LDL-C <55 mg/dL achieved (key secondary) · 6 months
- LDL-C <55 mg/dL achieved, protocol-based vs standard
- 60.8% vs 34.5%
- Between-group difference
- 26.3 percentage points (95% CI: 18.5-34.0); P < 0.001
Use of high-intensity statins, ezetimibe and PCSK9 inhibitors · 6 months
- Higher in the protocol-based group
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it