Pulmonary vascular disease & thromboembolismCohort study
Pulmonary arterial hypertension: right ventricular phenotyping to improve risk assessment at follow-up
- Prospective cohort study
- multicentre
- 11 centres
- Italian Pulmonary Hypertension NETwork (IPHNET)
Authors' conclusion
Echocardiography-derived phenotypes describing different degrees of RV remodelling and dysfunction provide prognostic information which is independent of and additional to the clinically defined risk in PAH patients at first follow-up.
Study context
- Population
- Patients with PAH re-evaluated 6–12 months after diagnosis (first follow-up)
- Exposure
- Echocardiography-derived right ventricular (RV) phenotypes within ESC/European Respiratory Society and REVEAL 2.0 risk groups
- Outcome
- All-cause death
- Follow-up
- Median 3.7 years
Main finding
As reported in the abstract
- Phenotypes present in all ESC/ERS or REVEAL 2.0 risk groups except high-risk groups, which included only phenotype-3 and phenotype-4
- In each risk group, RV phenotype-4 identified patients with poorer prognosis
- RV phenotype-1 identified patients with better survival in intermediate risk groups
Observational data: associations, not effects.
Original publication
Pulmonary arterial hypertension: right ventricular phenotyping to improve risk assessment at follow-up. Eur Heart J. Published 6 February 2026. doi:10.1093/eurheartj/ehag023
Summarised from the published abstract; every number is checked against it