Heart failure & cardiomyopathiesCohort study
Pulmonary Embolism-Attributable Mortality in Patients With Heart Failure in the United States, 2010 to 2020
- Data on pulmonary embolism (PE)-attributable mortality in heart failure (HF) patients aged ≥25 years were obtained from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database
- joinpoint regression
Authors' conclusion
PE-attributable mortality among U.S. patients with HF has risen significantly over the past decade particularly among younger adults, certain ethnoracial groups, and residents of the Midwest.
Study context
- Population
- U.S. patients with heart failure (HF) aged ≥25 years, 2010 to 2020U.S. patients with HF aged ≥25 years who died from PE · men 17,772 · women 20,357
- Participants
- 38,129 patients
Main finding
As reported in the abstract
Proportionate mortality from PE among HF deaths · 2010 to 2020
Proportionate mortality
97.5 per 1,000 deaths (≈9.8%)
Observational data: associations, not effects.
Further findings
AAMR trend · 2010 to 2020
- average annual percentage change
- +4.7%; 95% CI: 3.3%-6.1%; P < 0.001
- No sex differences (P for parallelism)
- 0.23
- linear increase
AAMR by subgroup
- AAMR increased among individuals aged 25 to 65 years, Asian/Pacific Islanders, non-Hispanic/non-Latinx Black individuals, and residents of the Midwest
HF prevalence and VTE risk factors
- Rises in age-adjusted rates of obesity, prior smoking, atherosclerotic cardiovascular disease, chronic kidney disease, and cancer
- P < 0.001 for all
- Age-adjusted prevalence of HF plateaued overall
Original publication
Pulmonary Embolism-Attributable Mortality in Patients With Heart Failure in the United States, 2010 to 2020. JACC Adv. doi:10.1016/j.jacadv.2026.102841
Summarised from the published abstract; every number is checked against it