Pulmonary vascular disease & thromboembolismCohort study
Pulmonary Hypertension in Adults With a Systemic Right Ventricle (Biventricular Circulation)
- retrospective cohort study
Authors' conclusion
In this large study evaluating the hemodynamic phenotype in patients with a systemic RV referred for catheterization, PH was common and most commonly the combined postcapillary and precapillary subtype.
Study context
- Population
- Adults with TGA-AS or congenitally corrected TGA (CCTGA) who had undergone invasive hemodynamic assessmentpatients studied · TGA-AS 161 · CCTGA 100
- Participants
- 261 adults
- Exposure
- TGA-AS vs CCTGA
- TGA-ASn = 161
- CCTGAn = 100
- Outcome
- Combined clinical endpoint: death, heart transplantation, or need for mechanical circulatory support
Main finding
As reported in the abstract
TGA-AS
24
CCTGA
29%
- Incidence similar in both groups
- P = 0.39
Observational data: associations, not effects.
Further findings
PH prevalence (mPAP >20 mm Hg)
- Pulmonary hypertension (PH) prevalence (mean pulmonary artery pressure (mPAP) >20 mm Hg) — similar in both groups
- P = 0.74
PH subtype
- precapillary
- 24%
- isolated postcapillary (IpcPH)
- 25%
- combined postcapillary and precapillary
- 51%
- similar in both groups
Relationship between pulmonary capillary wedge pressure and mPAP
- overall similar between 2 groups; greater variability in pulmonary capillary wedge pressure once mPAP >40 mm Hg in the TGA-AS group
Factors associated with the primary clinical endpoint
- elevated PVR (in particular, in the TGA-AS subgroup)
- lower aortic pulsatility index (both groups)
Original publication
Pulmonary Hypertension in Adults With a Systemic Right Ventricle (Biventricular Circulation). JACC Adv. Published 2 July 2026. doi:10.1016/j.jacadv.2026.102974
Summarised from the published abstract; every number is checked against it