Congenital heart diseaseCohort study
Pulmonary Valve Replacement in Tetralogy of Fallot
- Retrospective cohort study
- nationwide
Authors' conclusion
The PVR procedural volume has increased over time, with a greater increment in transcatheter than surgical PVR during the last decade. Younger patient age at PVR and a smaller true inner valve diameter predicted reduced BPV durability.
Study context
- Population
- Patients with tetralogy of Fallot undergoing pulmonary valve replacement (PVR), 1976–2021546 PVR
- Participants
- 384 patients
- Outcome
- Temporal trends in PVR procedural volume and BPV durability (time from implantation to redo PVR, death as competing risk)
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Age at PVR (per 10 years from <1 year)
0.78(0.63–0.96)
P = 0.02True inner valve diameter 9-17 mm vs 18-22 mm
0.40(0.22–0.73)
P = 0.003True inner valve diameter 18-22 mm vs 23-30 mm
0.59(0.25–1.39)
P = 0.23- Annual number of PVR increased from 0.4 to 6.0 per million population
- P < 0.001
- Transcatheter PVR volume increase per year, last decade
- 20%
- Median bioprosthetic pulmonary valve (BPV) durability
- 17 years (Q1: 10-Q3: 10 years-not applicable)
Observational data: associations, not effects.
Original publication
Pulmonary Valve Replacement in Tetralogy of Fallot. JACC Cardiovasc Interv. Published 20 December 2023. doi:10.1016/j.jcin.2023.10.070
Summarised from the published abstract; every number is checked against it