Pulmonary vasodilators and exercise in Fontan circulation: a systematic review and meta-analysis
Authors' conclusion
Although PAH-targeted therapies did not affect exercise parameters at maximal effort, they induced slight improvements in indices of submaximal effort, measured at the anaerobic threshold.
Study context
- Population
- Stable Fontan patients (mean age 21.2 years, 60% male)
- Participants
- 573 patients5 randomised controlled trials (RCTs)
- Comparison
- Pulmonary arterial hypertension (PAH)-targeted therapies vs control
- Outcome
- CPET parameters: peak VO2, peak HR, VE/VCO2 slope and VO2 at the anaerobic threshold (VO2@AT)
Pooled result
As reported in the abstract
PAH-targeted therapies vs ControlEstimate (95% CI)
Peak VO2; no effect
MD 0.72(−0.25 to 1.70)
Peak HR; no effect
MD −0.67(−3.81 to 2.47)
VO2@AT; small, significant improvement
SMD 0.24(0.02–0.47)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pulmonary vasodilators and exercise in Fontan circulation: a systematic review and meta-analysis. Heart. Published 2 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →