Arrhythmias & electrophysiologyCohort study
Pulmonary vein isolation using pulsed field ablation vs. high-power short-duration radiofrequency ablation in paroxysmal atrial fibrillation: efficacy, safety, and long-term follow-up (PRIORI study)
- Retrospective cohort study
- single-centre
Authors' conclusion
Both PFA and HPSD-RF were highly efficient and effective in achieving PVI in paroxysmal AF patients. The arrhythmia-free survival is comparable. The PV reconnection rate was not different.
Study context
- Population
- Consecutive patients with paroxysmal atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI), real-world setting
- Participants
- 410 patients
- Exposure
- PFA-PVI vs HPSD-RF PVI
- Pulsed field ablation (PFA)n = 201
- HPSD-RFn = 209reference
- Outcome
- Single-procedure freedom from any atrial tachyarrhythmia (Kaplan-Meier estimate)
- Follow-up
- 1 year
Main finding
As reported in the abstract
Freedom from any atrial tachyarrhythmia (Kaplan-Meier estimate)
log-rank P = 0.160
Observational data: associations, not effects.
Further findings
Procedure time
P < 0.001
Fluoroscopy time
P < 0.01
Dose area product
P < 0.01
PV reconnection rate at repeat ablation (56 procedures)
P = 0.372
Safety
Overall complications
P = 0.158
| Outcome | PFA | HPSD-RF | P value |
|---|---|---|---|
| Fatal stroke | 1 events | Not reported in the abstract |
Original publication
Pulmonary vein isolation using pulsed field ablation vs. high-power short-duration radiofrequency ablation in paroxysmal atrial fibrillation: efficacy, safety, and long-term follow-up (PRIORI study). Europace. Published 12 July 2024. doi:10.1093/europace/euae194
Summarised from the published abstract; every number is checked against it