Heart failure & cardiomyopathiesCohort study
Quantifying skeletal muscle energy metabolism during exercise in heart failure with preserved ejection fraction using in vivo 31P magnetic resonance spectroscopy
- parallel analysis of prospective studies
- two sites
Authors' conclusion
Patients with HFpEF exhibit impaired whole-muscle oxidative capacity of skeletal muscle, as shown by two different 31P-MRS protocols with upper leg measurements, independent of ID status.
Study context
- Population
- Patients with heart failure and preserved ejection fraction (HFpEF) and control individualsFifty-eight patients with HFpEF and 16 controls · isometric exercise HFpEF 46 · isometric exercise control 16 · cardiopulmonary exercise HFpEF 12
- Exposure
- patients with HFpEF and control individuals
- HFpEFn = Fifty-eight
- controln = 16
Main finding
As reported in the abstract
Phosphocreatine recovery halftime after isometric exercise
P = 0.03
Observational data: associations, not effects.
Further findings
| Outcome | HFpEF | control |
|---|---|---|
| Phosphocreatine recovery halftime after dynamic exercise | 39 (range as printed 27–57) seconds | Not reported in the abstract |
Exercise and oxidative muscle capacity, with vs without iron deficiency (ID)
- Isometric cohort with and without ID
- n = 19 and 27
- Cardiopulmonary cohort with and without ID
- n = 6 and 6
- comparable exercise and oxidative muscle capacity
- all P > .42
High-sensitive C-reactive protein and phosphocreatine recovery halftime
- associated with prolonged phosphocreatine recovery halftime
- P = . 01
Original publication
Quantifying skeletal muscle energy metabolism during exercise in heart failure with preserved ejection fraction using in vivo 31P magnetic resonance spectroscopy. ESC Heart Fail. Published 20 January 2026. doi:10.1093/eschf/xvaf035
Summarised from the published abstract; every number is checked against it