Quantitative cardiovascular magnetic resonance myocardial perfusion can discriminate significant cardiac allograft vasculopathy: a multi-centre study
Authors' conclusion
In this multi-centre retrospective study, MPR assessed by CMR could discriminate CAV2-3 with both high sensitivity and negative predictive value and a cut-off of MPR 2.2 is suggested.
Study context
- Population
- Patients with a heart transplant who had performed a clinical cardiovascular magnetic resonance (CMR) scan and invasive angiography
- Participants
- 110 patients
- Exposure
- Quantitative CMR myocardial perfusion (myocardial perfusion reserve (MPR)) against invasive angiography classified by the International Heart and Lung Transplantation cardiac allograft vasculopathy (CAV) classification
- CAV0n = 58
- CAV1n = 42
- CAV2-3n = 10
- Outcome
- Stress MP and MPR by CAV grade
Methodological detailstwo centres in Sweden
- Two centres in Sweden
Main finding
As reported in the abstract
- Gradual decrease of stress myocardial perfusion (MP) and MPR with increased CAV grade
Observational data: associations, not effects.
Further findings
Discrimination of CAV2-3 by MPR
- Area under the curve-receiver operating characteristic
- 0.88, 95% confidence interval 0.78-0.98
- Cut-off
- 2.2
- Sensitivity
- 100%
- Specificity
- 68%
- Positive predictive value
- 21
- Negative predictive value
- 100%
Original publication
Quantitative cardiovascular magnetic resonance myocardial perfusion can discriminate significant cardiac allograft vasculopathy: a multi-centre study. Eur Heart J Cardiovasc Imaging. Published 10 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it