Coronary disease & ACSRandomised controlled trial
Quantitative Coronary Angiography vs Intravascular Ultrasonography to Guide Drug-Eluting Stent Implantation
- Randomised controlled trial
- open-label
- non-inferiority
- multicentre (6 cardiac centres in Korea)
Authors' conclusion
Findings of this randomized clinical trial indicate that QCA and IVUS guidance during PCI showed similar rates of target lesion failure at 12 months.
Study context
- Population
- Adults with chronic or acute coronary syndrome and native coronary artery stenosis requiring percutaneous coronary intervention (PCI)
- Participants
- 1,528 adults
- Comparison
- Quantitative coronary angiography (QCA)-guided PCI vs intravascular ultrasonography (IVUS)-guided PCI
- QCAn = 763
- IVUSn = 765reference
- Primary endpoint
- Target lesion failure:
- Cardiac death
- Target vessel MI
- Ischemia-driven target lesion revascularization
- Follow-up
- 12 months
Primary result
As reported in the abstract
Each group vs IVUSAbsolute risk difference, percentage points (95% CI)
QCA
0.01(−1.91 to 1.93)
Non-inferiority margin 3.5 as printed, not drawn
Each group vs IVUSHazard ratio (95% CI)P value
QCA
1.00(0.60–1.68)
P = 0.99Non-inferiority margin 3.5 as printed, not drawn
Further findings
Post-PCI minimum lumen diameter
P = 0.26
Primary end point by subgroup
- Consistent regardless of subgroup, no significant interaction
Safety
Stent edge dissection
P = 0.25
Coronary perforation
P = 0.41
Stent thrombosis
P = 0.74
Original publication
Quantitative Coronary Angiography vs Intravascular Ultrasonography to Guide Drug-Eluting Stent Implantation. JAMA Cardiol. Published 1 May 2024. doi:10.1001/jamacardio.2024.0059
Summarised from the published abstract; every number is checked against it