Quantitative flow ratio as a continuous predictor of myocardial infarction
Authors' conclusion
The present study demonstrated a continuous, inverse relationship between the QFR value of a vessel and its subsequent risk for MI, and PCI, compared to medical therapy, reduced this risk beginning at a QFR value of 0.64.
Study context
- Population
- Vessels with reference diameter ≥2.5 mm and ≥1 lesion with diameter stenosis 50–90% in the FAVOR III China and PANDA-III trials5,564 + 4,471 vessels
- Comparison
- Percutaneous coronary intervention (PCI) vs medical therapy, by quantitative flow ratio (QFR)
- Outcome
- MI, by QFR as a continuous variable and vessel treatment (interaction)
- Follow-up
- 2 years
Methodological detailsoffline QFR
- Offline QFR
Pooled result
As reported in the abstract
MI
Net benefit of PCI over medical therapy for total myocardial infarction (MI) beginning at QFR
≤0.64
Further pooled results
Spontaneous MI, continuous QFR
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Continuous QFRInverse association | 0.89 (0.79–0.99) | P = 0.04 | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Spontaneous MI, continuous QFRPCI vs Medical therapy · association reduced by PCI | 0.26 (0.17–0.40) | P < 0.0001 | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Quantitative flow ratio as a continuous predictor of myocardial infarction. EuroIntervention. Published 7 August 2023. doi:10.
Summarised from the published abstract; every number is checked against it