Heart failure & cardiomyopathies
Quantitative Late Gadolinium Enhancement Cardiac Magnetic Resonance and Sudden Death in Hypertrophic Cardiomyopathy: A Meta-Analysis
Authors' conclusion
The different LGE quantification techniques have comparable accuracy in predicting SCD. When the more extensively studied 6 SD technique is used, LGE 10% is the optimal cutoff and can effectively restratify intermediate-risk patients.
Study context
- Population
- Adults with hypertrophic cardiomyopathy (HCM)
- Participants
- 5,550 adults · 11 studies
- Comparison
- Late gadolinium enhancement (LGE) quantification techniques for predicting sudden cardiac death (SCD)
- Manualn = 2
- 6 SDn = 7
- 4 SDn = 1
- 2 SDn = 1
- Outcome
- Prognostic value of LGE extent (LGE%) in predicting SCD
- Follow-up
- Median 5.2 years
Methodological detailsmultiple cutoffs model, Searched PubMed, Web of Science and Cochrane Library; pooled ORs with 95% CIs
- Multiple cutoffs model
- Searched PubMed, Web of Science and Cochrane Library; pooled ORs with 95% CIs
Pooled result
As reported in the abstract
Prediction of SCD by LGE quantification method
| Group | Optimal threshold | Sensitivity | Specificity |
|---|---|---|---|
| 6 SD | LGE 10% | 0.73 | 0.67 |
6 SD
Optimal thresholdLGE 10%
Sensitivity0.73
Specificity0.67
- No statistically significant difference in predicting SCD between the 4 methods
- P = 0.443
Original publication
Quantitative Late Gadolinium Enhancement Cardiac Magnetic Resonance and Sudden Death in Hypertrophic Cardiomyopathy: A Meta-Analysis. JACC Cardiovasc Imaging. Published 23 August 2023. doi:10.
Summarised from the published abstract; every number is checked against it