Acute cardiac care & resuscitation
Quantitative pupillometry index to prognosticate neurological outcome in unconscious cardiac arrest patients
- prospective observational study
- two University hospitals in Belgium and Spain
+1 more
- two University hospitals in Belgium and Spain
Authors' conclusion
Abnormal QPI had comparable specificity and a higher sensitivity than NPi in predicting UO at 3 months in comatose patients after CA.
Study context
- Population
- Unconscious (Glasgow Coma Scale <9) patients admitted to the Intensive Care Unit after successful resuscitation from cardiac arrest (CA), March 2022 to October 2024included in the final analysis, 193 screened
- Participants
- 111 participants
- Exposure
- This study compared the prognostic value of Neurological Pupil Index (NPi) and Quantitative Pupillometry Index (QPI) in patients after CA.
Main finding
As reported in the abstract
ICU mortality
ICU mortality
69 (62.2%)
Observational data: associations, not effects.
Further findings
| Outcome | QPI | NPi |
|---|---|---|
| Prediction of UO · 72 h | ||
| Threshold | ≤ 2 | ≤ 2 |
| Sensitivity | 60.4 [46.0-73.5]% | 24.5 [13.8-38.3]% |
| Specificity | 100 [87.2-100]% | 100 [86.8-100]% |
UO (Glasgow-Pittsburgh Cerebral Performance Category 3-5) · 3 months
- Patients with UO
- 79 (71%)
NPi and QPI in patients with UO · first three days
- Patients with UO showed a lower NPi and QPI during the first three days
Prediction of UO · 72 h
- The QPI showed an increasing positive predictive value over time
Original publication
Quantitative pupillometry index to prognosticate neurological outcome in unconscious cardiac arrest patients. Resuscitation. Published 20 February 2026. doi:10.1016/j.resuscitation.2026.111027
Summarised from the published abstract; every number is checked against it