Heart failure & cardiomyopathiesCohort study
Race and Socioeconomic Status Impact Diagnosis and Clinical Outcomes in Transthyretin Cardiac Amyloidosis
- Retrospective cohort study
- single-centre
Authors' conclusion
Black patients with low SES may be at greater risk for underdiagnosis and adverse outcomes compared with White patients.
Study context
- Population
- Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) receiving care at Johns Hopkins Hospital, 2006–2022225 (80%) men
- Participants
- 282 patients
- Exposure
- Black vs White patients; area deprivation index categories
- Blackn = 129
- Outcome
- HF hospitalization and/or death
Main finding
HF hospitalization or death · 5 years
Hazard ratio
2.77
95% CI 1.45–5.32
P = 0.002
Black vs White
HR 2.77 (95% CI 1.45–5.32); P = 0.002
As reported in the abstract
- Black patients more likely to have heart failure (HF) hospitalization or death over 5 years vs White
- log-rank P < 0.001
Observational data: associations, not effects.
Further findings
Highest ADI (most deprived) category
- Highest area deprivation index (ADI) (most deprived) category: P = 0.004
Original publication
Race and Socioeconomic Status Impact Diagnosis and Clinical Outcomes in Transthyretin Cardiac Amyloidosis. JACC CardioOncol. Published 18 June 2024. doi:10.1016/j.jaccao.2024.05.001
Summarised from the published abstract; every number is checked against it