Prevention & lipidsCohort study
Racial and Ethnic Differences in Long-Term Cardiovascular Mortality Among Women and Men From the Coronary Artery Calcium (CAC) Consortium
- Prospective cohort study
- multivariable Cox proportional hazards regression
- separate analyses by sex
Authors' conclusion
The disproportionately high and excess CV mortality among Black women and men represents significant barriers to reducing the burden of ASCVD through effective risk assessment using ASCVD risk and CAC scores.
Study context
- Population
- Women and men undergoing ASCVD risk assessment with CAC scoring, CAC Consortium, with self-reported race and ethnicity
- Participants
- 42,964 one-third women
- Exposure
- Black and Hispanic women and men vs other participants
- Blackn = 977
- Hispanicn = 1,349
- Asiann = 1,621
- American Indian/Native Alaskan/Hawaiian or unspecifiedn = 740
- Outcome
- CV mortality by ASCVD risk and CAC scores
- Follow-up
- Median 11.7 years
Main finding
As reported in the abstract
CV mortality
- Black vs other men · men with CAC ≥100
- HR 4.2; P < 0.001
- Hispanic vs White · men with CAC 0
- HR 3.6; P = 0.006
- Hispanic vs White · men with CAC ≥100
- HR 2.3; P = 0.03
- Similar high-risk pattern in Black women with CAC ≥100, even adjusted for ASCVD risk score
- P < 0.001
Observational data: associations, not effects.
Original publication
Racial and Ethnic Differences in Long-Term Cardiovascular Mortality Among Women and Men From the CAC Consortium. JACC Cardiovasc Imaging. Published 9 April 2025. doi:10.1016/j.jcmg.2025.01.013
Summarised from the published abstract; every number is checked against it