Acute cardiac care & resuscitation
Racial disparities in real-world outcomes of temporary mechanical circulatory support post-acute myocardial infarction
Authors' conclusion
The NHB individuals requiring tMCS after AMI had a similar bleeding risk but higher rates of ischaemic stroke, AKI, and cardiovascular events at longer follow-ups, while experiencing fewer mechanical complications of AMI.
Study context
- Population
- Non-Hispanic Black (NHB) and non-Hispanic White (NHW) adults who had acute myocardial infarction (AMI) and required temporary mechanical circulatory support (tMCS), TriNetX US collaborative network (2009–23)patients per cohort after PSM
- Participants
- 2,794 participants
- Comparison
- NHB vs NHW patients requiring tMCS following AMI
- NHBn = 2,794
- NHWn = 2,794reference
- Outcome
- Bleeding or ischaemic stroke
- Follow-up
- 7days, 30 days, 90 days, and 1 year
Methodological detailspropensity score matching (PSM) for age, sex, comorbid conditions, coronary artery procedures, and medications
- Propensity score matching (PSM) for age, sex, comorbid conditions, coronary artery procedures, and medications
Main finding
As reported in the abstract
Each group vs NHWHazard ratio (95% CI)
Ischaemic stroke at 90 days, NHB
1.28(1.01–1.64)
Ischaemic stroke at 1 year — NHB
1.43(1.15–1.78)
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortality, cardiac arrest, VF · 1 yearNHB vs NHW · all-cause mortality | 1.13 (1.03–1.24) | |
| All-cause mortality, cardiac arrest, VF · 1 yearNHB vs NHW · cardiac arrest | 1.18 (1.04–1.34) | |
| All-cause mortality, cardiac arrest, VF · 1 yearNHB vs NHW · VF | 1.20 (1.02–1.41) | |
| 0.512Hazard ratio (log scale) |
Acute kidney injury (AKI) · across all time
- NHB patients had an increased risk of AKI across all time
Mechanical complications of AMI · across all time points
- NHB individuals had a lower risk of mechanical complications of AMI across all time points
Other outcomes assessed
- No significant differences were observed in the other outcomes assessed
Original publication
Racial disparities in real-world outcomes of temporary mechanical circulatory support post-acute myocardial infarction. Eur Heart J Qual Care Clin Outcomes. Published 26 August 2025. doi:10.
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