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Coronary disease & ACSSecondary analysis

Radial wall strain for residual risk stratification after percutaneous coronary intervention

EuroInterventionPublished

  • post hoc study
  • blinded analysis
  • retrospective
  • using the TARGET All Comers randomised trial
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Authors' conclusion

In this retrospective post hoc analysis, RWS was independently associated with long-term adverse events in deferred non-target vessels, with its prognostic value most evident for subsequent non-target vessel revascularisation. Elevated baseline RWSmax was strongly associated with the NT-VOCE, with the highest predictive accuracy in vessels with high-quality angiographic imaging. Ongoing and planned prospective, randomised trials are evaluating the role of RWS-guided risk stratification.

Study context

Population
Patients enrolled in the TARGET All Comers randomised trial undergoing percutaneous coronary intervention; non-target vessels assessed by radial wall strain (RWS) from routine angiographyall enrolled patients, RWS successfully evaluated in 1,384 non-target vessels from 802 patients · non-target vessels with RWS evaluated 1,384 · patients with RWS evaluated 802
Participants
1,551 patients
Comparison
Baseline RWSmax for predicting the non-target vessel-oriented composite endpoint (NT-VOCE) in non-target vessels over 5 years
Primary endpoint
NT-VOCE (cardiac death, non-target vessel myocardial infarction and non-target vessel revascularisation)
Follow-up
5 years

Primary result

As reported in the abstract

Adjusted hazard ratio

4.82

95% CI 3.14–7.40

P < 0.0001

Baseline RWSmax
adjusted HR 4.82 (95% CI 3.14–7.40); P < 0.0001
adjusted AUC
0.73 (95% CI: 0.69-0.78; p<0.0001)

Further findings

NT-VOCE, subgroup with high-quality angiographic images

Comparisonadjusted HR (95% CI)P value
RWS · subgroup with high-quality angiographic images6.89 (3.15–15.07)P < 0.0001

Non-target vessel revascularisation

adjusted AUC
0.92, 95% CI: 0.88-0.95; p<0.0001

Original publication

Radial wall strain for residual risk stratification after percutaneous coronary intervention. EuroIntervention. Published 21 September 2026. doi:10.4244/eij-d-26-00126
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Summarised from the published abstract; every number is checked against it