Prevention & lipidsSecondary analysis
Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature
- Secondary analysis of the STRIP randomised controlled trial
- 20-year infancy-onset dietary intervention
Authors' conclusion
Infancy-onset 20-year dietary intervention had favourable effects on the retinal microvasculature in young adulthood. Several lifelong cumulative cardiovascular risk factors were independently associated with retinal microvascular structure.
Study context
- Population
- Young adults followed from infancy to age 26 years in the Special Turku Coronary Risk Factor Intervention Project
- Participants
- 486 adults
- Comparison
- Heart-healthy dietary intervention vs control
- Primary endpoint
- Retinal microvascular measures (arteriolar and venular diameters, tortuosity, fractal dimensions)
- Follow-up
- 26-year follow-up
Primary result
As reported in the abstract
Retinal microvasculature
- Less tortuous arterioles and venules and increased arteriolar fractal dimension with intervention vs control
- Intervention effects persisted when controlled for cumulative CV risk factors
Further findings
Lifelong cumulative saturated fat intake
- Reduced cumulative saturated fat intake associated with less tortuous venules
Lifelong cumulative CV risk factors
- Several cumulative risk factors independently associated with retinal microvascular measures, e.g. cumulative SBP with narrower arterioles
Original publication
Randomized 20-year infancy-onset dietary intervention, life-long cardiovascular risk factors and retinal microvasculature. Eur Heart J. Published 12 July 2024. doi:10.1093/eurheartj/ehae423
Summarised from the published abstract; every number is checked against it