Valvular & structural heart disease
A randomized comparison of the treatment sequence of percutaneous coronary intervention and transcatheter aortic valve implantation: Rationale and design of the transcatheter aortic valve implantation (TAVI) percutaneous coronary intervention (PCI) trial
Study context
- Population
- Patients with severe AS and concomitant CAD undergoing TAVI with Edwards SAPIEN 3 or 3 Ultra valveplanned enrolment
- Participants
- 986 patients
- Planned comparison
- Angiography-guided complete revascularisation after TAVI vs before TAVI
- Primary endpoint
- Composite of:
- All-cause death
- Nonfatal MI
- Ischemia-driven revascularization
- Rehospitalization (valve- or procedure-related incl. HF)
- Life-threatening/disabling or major bleeding
- Follow-up
- 1 year
Methodological detailsrationale and design, prospective, international, multicentre, 2-arm, open-label, non-inferiority, 1:1 randomisation
- Rationale and design
- Prospective
- International
- Multicentre
- 2-arm
- Open-label
- Non-inferiority
- 1:1 randomisation
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
A randomized comparison of the treatment sequence of percutaneous coronary intervention and transcatheter aortic valve implantation: Rationale and design of the TAVI PCI trial. Am Heart J. Published 8 August 2024. doi:10.
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