Heart failure & cardiomyopathies

Randomized controlled trial of urinE chemiStry guided aCute heArt faiLure treATmEnt (ESCALATE): Rationale and design

Am Heart JPublished Randomised controlled trial

Study context

Population
Patients hospitalized for acute HF with hypervolemia (≥10 pounds estimated excess volume); excluding significant valvular stenosis, hypotension, chronic dialysisplanned
Participants
450 patients
Planned comparison
Urine chemistry-guided diuresis vs usual care
Primary endpoint
Days of benefit
Follow-up
14 days after randomization
Methodological detailsrationale and design
  • Rationale and design

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Randomized controlled trial of urinE chemiStry guided aCute heArt faiLure treATmEnt (ESCALATE): Rationale and design. Am Heart J. Published 6 August 2023. doi:10.1016/j.ahj.2023.07.014

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