Acute cardiac care & resuscitation
A randomized trial of expedited intra-arrest transfer versus more extended on-scene resuscitation for refractory out of hospital cardiac arrest: Rationale and design of the EVIDENCE trial
Study context
- Population
- Adults aged 18 to 70 with witnessed refractory OHCA, assumed medical cause, immediate bystander cardiopulmonary resuscitation (CPR), initial ventricular fibrillation (VF)/pulseless ventricular tachycardia (VT) or Pulseless Electrical Activity (PEA), no ROSC after 3 shocks and/or 15 minutes of professional on-scene resuscitation, mechanical CPR available; 2 urban regions in NSW Australiaplanned, 1:1
- Participants
- 200 adults
- Planned comparison
- Expedited transport from scene vs ongoing advanced life support (ALS) on-scene
- Primary endpoint
- Survival to hospital discharge with cerebral performance category (CPC) 1 or 2
- Follow-up
- Hospital discharge
Methodological detailsrationale and design, phase III, multicentre, partially blinded, prospective, intention-to-treat, contemporaneous registry of ineligible patients, Secondary outcomes: safety, survival, prognostic factors, ECMO-supported CPR, functional assessment at discharge, 4 weeks and 6 months, quality of life, healthcare use, cost-effectiveness
- Rationale and design
- Phase III
- Multicentre
- Partially blinded
- Prospective
- Intention-to-treat
- Contemporaneous registry of ineligible patients
- Secondary outcomes: safety, survival, prognostic factors, ECMO-supported CPR, functional assessment at discharge, 4 weeks and 6 months, quality of life, healthcare use, cost-effectiveness
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
A randomized trial of expedited intra-arrest transfer versus more extended on-scene resuscitation for refractory out of hospital cardiac arrest: Rationale and design of the EVIDENCE trial. Am Heart J. Published 21 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it