Arrhythmias & electrophysiologyRandomised controlled trial
Randomized Invitation to Systematic NT-proBNP and ECG Screening in 75-Year-Olds to Detect Atrial Fibrillation: STROKESTOP II
- Randomised controlled trial
- population-based
- 1:1 randomisation
Authors' conclusion
In this population-based screening trial for atrial fibrillation using NT-proBNP for screening enhancement, there was no difference in risk of stroke or systemic embolism for the intervention group compared with controls.
Study context
- Population
- All 75- and 76-year-olds in Stockholm Region, Swedenrandomized
- Participants
- 28,712 participants
- Comparison
- Invitation to NT-proBNP-enhanced AF screening vs control
- Interventionn = 13,905
- Controln = 13,884reference
- Primary endpoint
- Stroke or systemic embolism
- Follow-up
- Median 5.1 years (IQR, 5.0-5.8)
Primary result
As reported in the abstract
median 5.1 years
Hazard ratio
0.96
95% CI 0.86–1.06
Intervention vs Control
HR 0.96 (95% CI 0.86–1.06)
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Stroke or systemic embolism, low NT-proBNP (subgroup) | 0.59 (0.46–0.74) | P < 0.001 | |
| Stroke or systemic embolism, high vs low NT-proBNP (subgroup) | 1.57 (1.22–2.02) | P = 0.001 | |
| 0.512Hazard ratio (log scale) |
| Outcome | Intervention | Control | Estimate | P value |
|---|---|---|---|---|
| New AF detected | 2.4% | Not reported in the abstract |
- Participation in intervention group
- 49.2% · 6843 of 13 905
- New AF detected: of 6843 participants
AF prevalence and OAC treatment · 5 years
- No difference between intervention and control
Original publication
Randomized Invitation to Systematic NT-proBNP and ECG Screening in 75-Year-Olds to Detect Atrial Fibrillation: STROKESTOP II. Circulation. Published 1 September 2024. doi:10.1161/circulationaha.124.071176
Summarised from the published abstract; every number is checked against it