Heart failure & cardiomyopathiesCross-sectional study
Rare Variant Genetics and Dilated Cardiomyopathy Severity: The Dilated Cardiomyopathy (DCM) Precision Medicine Study
- Cross-sectional study
- multisite
- multinomial models with generalized logit link
Authors' conclusion
Advanced DCM was associated with higher odds of rare variants in DCM genes adjudicated as pathogenic or likely pathogenic, compared with individuals with less severe DCM.
Study context
- Population
- Patients with DCM in the US multisite DCM Precision Medicine Study, enrolled 2016–2021; multiracial, multiethnic cohort
- Participants
- 1,198 patients
- Exposure
- Rare variant genetic findings by DCM severity
- LVAD/HTn = 347
- Implantable cardioverter defibrillator (ICD)n = 511
- No LVAD/HT or ICDn = 340reference
- Outcome
- Pathogenic or likely pathogenic rare variants in 36 DCM genes
Main finding
Pathogenic or likely pathogenic variants
Odds ratio
2.3
95% CI 1.5–3.6
By group
LVAD/HT vs No LVAD/HT or ICD
OR 2.3 (95% CI 1.5–3.6)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study. Circulation. Published 29 August 2023. doi:10.1161/circulationaha.123.064847
Summarised from the published abstract; every number is checked against it