Heart failure & cardiomyopathiesTrial design
Rationale and design of the TAILOR-HCM multicenter randomized controlled trial: Transapical beating-heart septal myectomy for obstructive hypertrophic cardiomyopathy
- multicenter, randomized, controlled, assessor-blinded, noninferiority trial
- 11 experienced conventional septal myectomy (CSM) centers in China
- 1:1 randomization
- trial rationale and design (no results)
Study context
- Population
- Symptomatic patients with obstructive hypertrophic cardiomyopathy (oHCM) who meet guideline-directed indications for septal myectomyplanned enrolment
- Participants
- 216 patients
- Planned comparison
- TA-BSM vs CSM
- Primary endpoint
- Relief of left ventricular outflow tract (LVOT) obstruction (resting LVOT gradient <30 mm Hg and standardized Valsalva maneuver-provoked LVOT gradient <50 mm Hg)
- Follow-up
- 12 months
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Rationale and design of the TAILOR-HCM multicenter randomized controlled trial: Transapical beating-heart septal myectomy for obstructive hypertrophic cardiomyopathy. Am Heart J. Published 22 July 2026. doi:10.1016/j.ahj.2026.107543
Summarised from the published abstract; every number is checked against it