Coronary disease & ACSTrial design

Rationale and design of the vericiguat in vasospastic angina (ViVA) trial: A double-blind placebo-controlled randomized cross-over study

Am Heart JPublished

  • double-blind placebo-controlled randomized cross-over study
  • randomized in a 1:1 ratio

Study context

Population
Patients with coronary vasospasm as the pathophysiological substrate of angina and no obstructive coronary arteries (ANOCA)planned enrolment
Participants
50 patients
Planned comparison
vericiguat vs placebo

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Rationale and design of the vericiguat in vasospastic angina (ViVA) trial: A double-blind placebo-controlled randomized cross-over study. Am Heart J. Published 23 April 2026. doi:10.1016/j.ahj.2026.107451

Summarised from the published abstract; every number is checked against it