Arrhythmias & electrophysiologyCohort study
Reablation of atrial fibrillation targeting electrogram dispersion in patients with isolated veins: The RESTART trial
- interventional, prospective, single-arm, multicenter clinical trial
Authors' conclusion
In patients with documented isolated PVs, AI-guided dispersion ablation is safe and effective and represents an alternative to other ablative strategies.
Study context
- Population
- Patients with previous catheter or surgical ablation for paroxysmal, persistent, or long-standing persistent atrial fibrillation (AF), documented symptomatic AF recurrences and pulmonary vein (PVs) that remain isolated, undergoing a repeat ablationenrolled, premature study exit for PV reconnection (n = 80) or noninducibility of AF (n = 14), primary endpoint assessed in 93
- Participants
- 213 patients
- Outcome
- Freedom from documented AF after a single AI-guided repeat ablation procedure
- Follow-up
- 12 months
Main finding
As reported in the abstract
Artificial intelligence (AI)-guided repeat ablation
83%
77 of 93 events
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Freedom from any atrial arrhythmia after a single procedure | AI-guided repeat ablation 70% |
AF termination during ablation
- AF termination during ablation
- 54%
Right atrial dispersion identified
- right atrial dispersion was identified
- 59%
Quality of life (AF Effect on Quality-of-Life questionnaire and 36-Item Short Form Survey scores)
- Improvements in quality-of-life metrics
Original publication
Reablation of atrial fibrillation targeting electrogram dispersion in patients with isolated veins: The RESTART trial. Heart Rhythm. Published 2 February 2026. doi:10.1016/j.hrthm.2026.01.042
Summarised from the published abstract; every number is checked against it