Valvular & structural heart diseaseCohort study
Real-World Outcomes for the Fifth-Generation Balloon Expandable Transcatheter Heart Valve in the United States
- Retrospective cohort study
- propensity-matched
- registry-based
Authors' conclusion
S3UR TAVR is associated with lower mean gradients and lower rates of PVL than earlier generations of balloon expandable transcatheter heart valve platforms.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR) with balloon expandable valves in the STS/ACC TVT Registry, January 2021–June 2023matched from 150,539 S3U/S3
- Participants
- 10,314 vs 10,314
- Exposure
- S3UR vs S3/S3U
- S3URn = 10,314
- S3/S3Un = 10,314reference
Main finding
As reported in the abstract
30-day death, stroke, bleeding and hospital readmission · 30 days
- No statistically significant differences in death, stroke or bleeding
- S3UR vs S3/S3U: P = 0.04
- propensity-matched
Observational data: associations, not effects.
Further findings
Mean gradient · discharge
P < 0.0001
Aortic valve area · discharge
P < 0.0001
Mild paravalvular leak (PVL), 29-mm valve size
- 29-mm valve: significant reduction in mild PVL, 5.3% vs 9.4%
- P < 0.0001
Original publication
Real-World Outcomes for the Fifth-Generation Balloon Expandable Transcatheter Heart Valve in the United States. JACC Cardiovasc Interv. Published 8 March 2024. doi:10.1016/j.jcin.2024.02.015
Summarised from the published abstract; every number is checked against it