Heart failure & cardiomyopathies
Real-World Outcomes in Cardiac Resynchronization Therapy Patients: Primary Results of the SMART Registry
Authors' conclusion
As defined by CCS, 58.9% of patients improved and 20.1% stabilized. Patients with AF had particularly worse clinical outcomes, higher HF hospitalization and mortality rates and lower percentages of ventricular pacing.
Study context
- Population
- Real-world patients receiving de novo CRT-defibrillator (CRT-D) implants or upgrade from pacemaker or ICD to CRT-D, using a quadripolar LV lead1,558 with completed 12-month clinical composite score (CCS)
- Participants
- 2,035 patients
- Outcome
- CRT response by clinical composite score (CCS:
- All-cause mortality
- HF hospitalization
- New York Heart Association (NYHA) class
- Quality of life global assessment)
- Follow-up
- Baseline to 12 months
Methodological detailsglobal, multicentre
- Global
- Multicentre
Main finding
As reported in the abstract
CCS at 12 months
Improved
58.9%
n = 917
Stabilized
20.1%
n = 313
Worsened
21.0%
n = 328
Observational data: associations, not effects.
Further findings
HF hospitalization, AF non-LBBB vs non-AF LBBB (subgroup)
P < 0.001
- Heart failure (HF) hospitalization, atrial fibrillation (AF) non-LBBB vs non-AF LBBB (subgroup) — Mortality between subgroups statistically significant
- P = 0.019
Predictors of lower likelihood of cardiac resynchronization therapy (CRT) response
- Older age, ischaemic aetiology, renal dysfunction, AF, non-LBBB morphology and diabetes associated with lower likelihood of response
Outcomes in patients with AF (subgroup)
- Higher HF hospitalization with AF
- P < 0.001
- Higher all-cause mortality with AF
- P < 0.001
- Lower percentages of ventricular pacing with AF than sinus rhythm at baseline and follow-up
- P < 0.001, both
Original publication
Real-World Outcomes in Cardiac Resynchronization Therapy Patients: Primary Results of the SMART Registry. ESC Heart Fail. Published 26 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →