Aortic & peripheral vascular diseaseCohort study
Real-World Outcomes of Carotid Artery Stenting in Symptomatic and Asymptomatic Patients With Carotid Artery Stenosis
- Retrospective registry study
- nationwide
- 156 centres
- consecutive patients
- Embolism protection devices used in 99% of patients
Authors' conclusion
The complication rate after specialist-involved CAS at 30 days was low in real-world practice.
Study context
- Population
- Consecutive patients with carotid artery stenosis undergoing carotid artery stenting (CAS) by certified specialists of the Japanese Society of Neuroendovascular Therapy, 2015–2019analysed
- Participants
- 9,792 patients
- Exposure
- Symptomatic vs asymptomatic patients undergoing CAS
- Symptomaticn = 5,351
- Asymptomaticn = 4,441reference
- Outcome
- Composite of:
- Ischemic stroke
- All-cause death
- Follow-up
- 30 days after CAS
Main finding
As reported in the abstract
Adjusted odds ratio
1.30
95% CI 0.92–1.83
Events by group
Symptomatic vs Asymptomatic
adjusted OR 1.30 (95% CI 0.92–1.83)
Observational data: associations, not effects.
Secondary outcomes
Other secondary outcomes (ischemic stroke, all-cause death, other procedural complications)
- Not significantly different between the 2 groups
Safety
| Outcome | Symptomatic | Asymptomatic | aOR (95% CI) | |
|---|---|---|---|---|
| Symptomatic ICH | 0.9% | 0.2% | 4.41 (1.68–11.6) | |
| Any ICH | 1.4% | 0.3% | 3.56 (1.71–7.39) | |
| Acute in-stent occlusion | 0.8% | 0.4% | 2.18 (1.08–4.40) | |
| Hyperperfusion syndrome | 1.9% | 0.8% | 1.78 (1.17–2.71) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Original publication
Real-World Outcomes of Carotid Artery Stenting in Symptomatic and Asymptomatic Patients With Carotid Artery Stenosis. JACC Cardiovasc Interv. Published 13 May 2024. doi:10.1016/j.jcin.2024.03.014
Summarised from the published abstract; every number is checked against it