Arrhythmias & electrophysiologyCohort study
Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study
- global, prospective, observational study
- postapproval registry
Authors' conclusion
In routine practice, iATP was highly effective and safe across all VT rates. Although exploratory, iATP had overall superior termination rates and a lower chance of acceleration resulting in shock than standard ATP.
Study context
- Population
- Patients with an Intrinsic ATP (iATP)-enabled implantable cardioverter-defibrillator or cardiac resynchronization therapy-defibrillator deviceenrolled patients, followed for a total of 3200 patient-years, yielding 2575 iATP-treated monomorphic ventricular tachycardia (MVT) episodes
- Participants
- 1,875 patients
- Exposure
- iATP effectiveness in terminating MVT episodes in the fast ventricular tachycardia (VT) zone against >60% objective; post hoc comparison of iATP with standard antitachycardia pacing (ATP) from a retrospective cohort
- iATPn = 1,875
- Outcome
- Termination of MVT episodes in the fast VT zone (objective >60%)
Main finding
As reported in the abstract
iATP
89.7%
Generalized estimating equations (GEE)-estimated success rate · 95% CI 83.6–93.7
Observational data: associations, not effects.
Further findings
| Outcome | adjusted odds ratio (95% CI) | P value | |
|---|---|---|---|
| VT termination, iATP vs standard ATP (post hoc) · post hoc, exploratory | 1.87 (1.32–2.66) | P = 0.0005 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Safety
| Outcome | iATP | standard ATP | adjusted odds ratio (95% CI) | P value | |
|---|---|---|---|---|---|
| iATP-associated MVT acceleration resulting in shock · post hoc, exploratory | GEE-estimated rate 2.3% | Not reported in the abstract | 0.43 (0.25–0.74) | P = 0.0026 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Real-world performance of intrinsic antitachycardia pacing: Primary results from a global prospective postapproval registry study. Heart Rhythm. Published 5 January 2026. doi:10.1016/j.hrthm.2025.12.039
Summarised from the published abstract; every number is checked against it