Drug-Coated Balloon Angioplasty vs Drug-Eluting Stents in Noncomplex Coronary Bifurcation Lesions: The REC-CAGEFREE I Trial
Authors' conclusion
DCBs were associated with a numerically comparable risk for DoCE compared with DES in noncomplex bifurcations at 2 years.
Study context
- Population
- Patients with de novo noncomplex coronary lesions, stratified by bifurcation vs nonbifurcation2,257 analysed
- Participants
- 2,272 patients
- Comparison
- DCB vs drug-eluting stents (DES) in bifurcation and nonbifurcation lesions
- Primary endpoint
- Device-oriented composite endpoint (DoCE)
- Follow-up
- 24 months
Methodological detailsprespecified subgroup analysis, investigator-initiated, non-inferiority, multicentre (43 sites in China), inverse probability of treatment weighting (IPTW)-adjusted
- Prespecified subgroup analysis
- Investigator-initiated
- Non-inferiority
- Multicentre (43 sites in China)
- IPTW-adjusted
Primary result
As reported in the abstract
DoCE by bifurcation status (subgroups)
HRIPTW
2.67
95% CI 1.64–4.33P < 0.001
nonbifurcation: 46 of 735 (6.3%) vs 18 of 749 (2.4%)
HRIPTW
1.03
95% CI 0.53–2.01P = 0.934
bifurcation: 26 of 394 (6.7%) vs 20 of 379 (5.3%)
Further findings
| Outcome | HRIPTW (95% CI) | P value |
|---|---|---|
| DoCE, bifurcation vs nonbifurcation · 24 months46 of 773 (6.0%) vs 64 of 1,484 (4.3%) | 1.39 (0.87–2.21) | P = 0.164 |
Original publication
Drug-Coated Balloon Angioplasty vs Drug-Eluting Stents in Noncomplex Coronary Bifurcation Lesions: The REC-CAGEFREE I Trial. JACC Cardiovasc Interv. Published 26 March 2026. doi:10.
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