Coronary disease & ACSResearch article

Reconsidering fibrinolysis in selected patients with non–ST-elevation acute coronary syndrome: A hypothesis-generating, research-based framework

Am Heart JPublished

  • hypothesis-generating, research-based framework

Authors' conclusion

This article does not propose a change in clinical practice. Instead, it outlines a hypothesis-generating, research-based framework to explore whether, in highly selected circumstances and in the absence of timely PCI, fibrinolytic therapy could be studied in NSTE-ACS patients with probable acute coronary occlusion identified by advanced diagnostic tools.

Study context

Population
Selected non-ST-elevation acute coronary syndrome (NSTE-ACS) patients in whom timely angiographic evaluation or percutaneous coronary intervention (PCI) is unavailable

Original publication

Reconsidering fibrinolysis in selected patients with non–ST-elevation acute coronary syndrome: A hypothesis-generating, research-based framework. Am Heart J. Published 31 July 2026. doi:10.1016/j.ahj.2026.107548

Summarised from the published abstract; every number is checked against it