Heart failure & cardiomyopathiesCohort study
Recovery of Left Ventricular Function and Long-Term Outcomes in Patients With Takotsubo Syndrome
- Prospective registry cohort study
- nationwide
- multicenter
Authors' conclusion
Late recovery of LV function after TTS is associated with reduced short- and long-term survival.
Study context
- Population
- Patients with Takotsubo syndrome (TTS) in the RETAKO registrymedian age 73 years, 13% men
- Participants
- 1,463 patients
- Exposure
- Late vs early left ventricular (LV) recovery
- Late recoveryn = 373
- Early recoveryn = 1,090reference
- Outcome
- All-cause mortality
- Follow-up
- 4-year follow-up
Main finding
As reported in the abstract
Adjusted hazard ratio (95% CI)
Late recovery vs Early recovery
1.31(1.12–1.60)
every additional 10-day delay in time-to-LV recoveryrisk of death increasing by 8%
1.08(1.04–1.13)
Observational data: associations, not effects.
Further findings
Independent predictors of late recovery
- Older age, history of neurological disorders, bystander CAD, active cancer, physical triggers, elevated inflammatory biomarkers, cardiogenic shock and lower LVEF at admission
Original publication
Recovery of Left Ventricular Function and Long-Term Outcomes in Patients With Takotsubo Syndrome. J Am Coll Cardiol. Published 24 September 2024. doi:10.1016/j.jacc.2024.05.075
Summarised from the published abstract; every number is checked against it