Recurrent Aortic Dissection: Observations From the International Registry of Aortic Dissection
Authors' conclusion
Among those suffering acute aortic dissection, 5% have a history of a prior aortic dissection. Recurrent AD is strongly associated with Marfan syndrome.
Study context
- Population
- Patients with acute aortic dissection enrolled in IRAD
- Participants
- 204 vs 3,624
- Exposure
- Recurrent aortic dissection (AD) vs initial AD
- Recurrent ADn = 204
- Initial ADn = 3,624reference
- Outcome
- Patient characteristics, interventions and outcomes, recurrent vs initial AD
Methodological detailsIRAD international registry
- IRAD international registry
Main finding
As reported in the abstract
Patient characteristics, recurrent vs initial AD
| Group | Descending aortic dimension, sentinel type A | Descending aortic dimension, sentinel type B |
|---|---|---|
| Recurrent AD | 4.3 cm [3.5-5.6 cm] | 5.0 cm [3.9-6.0 cm] |
| Initial AD | 3.3 cm [2.9-3.7 cm] | 4.0 cm [3.5-4.8 cm] |
Descending aortic dimension, sentinel type A
Recurrent AD4.3 cm [3.5-5.6 cm]
Initial AD3.3 cm [2.9-3.7 cm]
Descending aortic dimension, sentinel type B
Recurrent AD5.0 cm [3.9-6.0 cm]
Initial AD4.0 cm [3.5-4.8 cm]
- Recurrent AD vs Initial AD: P < 0.001 — Marfan syndrome 21.5% vs 3.1%
- Recurrent AD vs Initial AD: P = 0.77 — bicuspid aortic valve 3.6% vs 3.2%
- Recurrent AD vs Initial AD: P < 0.001 — descending aortic dimension, type A
- Recurrent AD vs Initial AD: P < 0.001 — descending aortic dimension, type B
Observational data: associations, not effects.
Further findings
Marfan syndrome as independent predictor of recurrent AD (multivariate)
| Comparison | HR (95% CI) | P value | |
|---|---|---|---|
| Marfan syndrome | 8.6 (5.8–12.8) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Age, recurrent AD by sequence of dissection
P = 0.004
Original publication
Recurrent Aortic Dissection: Observations From the International Registry of Aortic Dissection. Circulation. Published 1 September 2016. doi:10.
Summarised from the published abstract; every number is checked against it