Heart failure & cardiomyopathies
Recurrent Heart Failure Hospitalizations in Heart Failure with Preserved Ejection Fraction: An Analysis of TOPCAT Trial
Authors' conclusion
In patients with HFpEF, the majority of HFHs occur in a small proportion of patients with repeated hospitalizations, who typically have more comorbidities and are at higher risk of death.
Study context
- Population
- HFpEF patients in TOPCAT enrolled in the AmericasAmericas subset
- Participants
- 1,767 patients
- Comparison
- Recurrent heart failure hospitalization (HFH) vs non-recurrent HFH
- Recurrent HFHn = 163
- Primary endpoint
- Recurrent HFH (≥2 HF hospitalizations); risk factors and prediction model
- Follow-up
- Median 3.4 years
Methodological detailsrisk prediction model, Americas subset
- Risk prediction model
- Americas subset
Primary result
As reported in the abstract
Recurrent HFH
| Group | Value | Share of HFH events |
|---|---|---|
| Recurrent HFH | 9.4% | 72.2% (542 of 751 total hospitalizations) |
Recurrent HFH
Value9.4%
Share of HFH events72.2% (542 of 751 total hospitalizations)
- 9-predictor model, moderate predictive power: AUC
- 0.75
- Brier score
- 0.08
Further findings
Per 100 patient-years (PY)
| Outcome | Recurrent HFH | Non-recurrent HFH | P value |
|---|---|---|---|
| CV mortality | 6.2 | 3.8 | P = 0.016 |
| All-cause mortality | 10.0 | 6.8 | P = 0.015 |
Original publication
Recurrent Heart Failure Hospitalizations in Heart Failure with Preserved Ejection Fraction: An Analysis of TOPCAT Trial. ESC Heart Fail. Published 6 December 2023. doi:10.
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