Coronary disease & ACSRandomised controlled trial
Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial
- Analysis of patients from the Myocardial Ischemia and Transfusion (MINT) trial
- randomized to a liberal vs restrictive red blood cell transfusion strategy
- centralized review of troponin levels collected for 3 days following randomization
Authors' conclusion
In patients with acute MI and anemia, centralized troponin review identified more than half of all recurrent MI events. Patients with centrally identified MI had a higher risk of cardiac death than those with no recurrent MI.
Study context
- Population
- Patients with acute myocardial infarction (MI) and anemiapatients in the MINT trial
- Participants
- 3,504 patients
- Comparison
- Differences in cardiac, noncardiac, and all-cause death at 30 and 180 days were compared across patients with any site-reported MI, only centrally identified MI, and no recurrent MI.
- site-reported MIn = 119
- only centrally identified MIn = 156
Primary result
As reported in the abstract
Recurrent MI · within 30 days
Recurrent MI, of 3,504 patients
275 (7.8%)
By site-report, of the 275 recurrent MIs
119 (43.3%)
By central troponin review only, of the 275 recurrent MIs
156 (56.7%)
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Cardiac death · 30 days and 180 days — only centrally identified MI vs no recurrent MI · 30 days | 1.9 (1.0–3.4) | |
| Cardiac death · 30 days and 180 days — only centrally identified MI vs no recurrent MI · 180 days | 1.7 (1.1–2.7) | |
| 0.20.5125Relative risk (log scale) |
Cardiac, all-cause and noncardiac death · 30 and 180 days
- Rates of cardiac and all-cause death highest for site-reported MI, intermediate for centrally identified MI, and lowest for no recurrent MI
- Rates of noncardiac death did not vary
Original publication
Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial. Am Heart J. Published 9 August 2026. doi:10.1016/j.ahj.2026.107553
Summarised from the published abstract; every number is checked against it