Coronary disease & ACSCohort study
Reducing gap in pre-hospital delay between women and men presenting with ST-elevation myocardial infarction
- Registry-based cohort study
- multivariable quantile regression
Authors' conclusion
Over two decades, delay between symptom onset and hospital admission in STEMI decreased significantly for men and women. The decline was more pronounced in women, leading to the sex gap disappearing in the adjusted analysis for 2019.
Study context
- Population
- Patients admitted for ST-elevation myocardial infarction (STEMI) in Switzerland, AMIS Plus registry, 2002–201974.5% men
- Participants
- 15,350 patients
- Exposure
- Women vs men
- Outcome
- Pre-hospital delay (symptom onset to hospital admission) over time by sex
Main finding
As reported in the abstract
Pre-hospital delay (symptom onset to hospital admission), 2002–2019
| Group | Value | Adjusted change in delay |
|---|---|---|
| Men | median 150 (IQR 84–345) min | −1.6 min per year |
| Women | median 180 (IQR 100–414) min | −3.3 min per year |
- Unadjusted sex difference in delay, 2002
- 60 min (P = 0.0042)
- Unadjusted sex difference in delay, 2019
- 40.5 min (P = 0.165)
- Interaction between sex and admission year (multivariable model); decrease stronger for women
- P = 0.038
- Adjusted difference between men and women, 2002
- 26.93 min
- Adjusted difference between men and women, 2019
- −1.97 min for women
Observational data: associations, not effects.
Original publication
Reducing gap in pre-hospital delay between women and men presenting with ST-elevation myocardial infarction. Eur J Prev Cardiol. Published 13 December 2022. doi:10.1093/eurjpc/zwac294
Summarised from the published abstract; every number is checked against it